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Studies designed to provide insight into clinical practice in the real world are called pragmatic trials. They are often described as focusing on practical aspects of design, including the recruitment process and consent, adhering and the use routinely available equipment.
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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographical regions. This type of heterogeneity is essential for practical trials to be valid and also reduces bias in the results. However excessive heterogeneity could result in problems with the design of the trial.
Pragmatic Play, a major player on the live casino market offers an array of traditional table games like Blackjack and Roulette. The live studios of Pragmatic Play's offices in Romania and Malta provide customers with an authentic gaming experience as well a full selection of virtual betting options. The company has also created various interactive games to make gambling online enjoyable. Some of these shows have live hosts, whereas others are hosted by famous personalities from the industry.
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Legality
Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. It has established itself as one of the top casino gaming platforms despite its relative youth. The most recent releases include Wolves, a 5-reel video slot with a healthful RTP and impressive graphics. Its other notable titles are Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. They are usually requested by policy makers and practitioners to guide their decision-making. They are also a good way to identify the cause-effect relationship between an intervention and its results. However, they shouldn't be used as a substitute for explanation trials.
The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support the validity of a physiological or clinical hypothesis, and pragmatic trials, that inform the practice and policy decision-making. They also suggested the framework for pragmatic trials, dubbed PRECIS.2 This tool attempted to define the characteristics of a practical trial which includes the recruitment process, the design and implementation of the intervention, as well as the follow-up.
The number of pragmatic trials is growing. A recent Medline search using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This suggests that the health sciences community has become more aware of the importance of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary care settings.